| abstract |
After separating the benzyl group from (S, S, S) -2-azabicyclo (3,3,0) -octane-3-carboxylic acid benzyl ester, this was followed by N- [1 (S) -ethoxycarbonyl- A method for preparing ramipril by reacting with 3-phenylpropyl] -L-alanine-N-carboxy anhydride is disclosed. Since it does not use Pd / C (carbon-containing palladium catalyst) and hydrogen gas, it has advantages in that it is excellent in work safety and does not cause a problem of disposal of metal materials remaining after the reaction, and also has excellent production efficiency. |