http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20090124203-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2dbfc26e9c9cb93d9d25270b67913573 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-30 |
| filingDate | 2008-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3029b1fde98738bf91fd7c08beee797a |
| publicationDate | 2009-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20090124203-A |
| titleOfInvention | Drug delivery system |
| abstract | The present invention provides a composition comprising (a) a biocompatible polymer; And (b) a hydrophobic group conjugated to the polymer. Drug carriers composed of biocompatible polymers conjugated with hydrophobic groups prepared by the present invention can be usefully used for adsorption of synthetic drugs having very low solubility in water. In addition, the drug carrier according to the present invention has an advantage of controlling the release rate of the adsorbed drug through controlling the content of the hydrophobic group conjugated to the polymer material. Accordingly, the present invention provides a broad-spectrum platform technology that can be applied to newly developed hydrophobic synthetic drugs or drugs that have already been developed but are suffering from low bioavailability problems. . The drug carrier according to the present invention can provide a convenient treatment to patients in the future by adsorbing a hydrophobic drug having a low bioavailability with the drug carrier to be delivered to the body and having a sustained release property of the drug in the body.n n n The drug carrier according to the present invention is also applicable to protein medicines. First-generation protein drugs that have expired patents that require injections every day or once every 2-3 days have been tried to improve patient convenience, and recently, once a week or once or twice a month Second generation injection formulations have been developed and are commercially available. In this patent, the first generation protein refers to a biopharmaceutical based on a commercially available natural protein produced by genetic recombination techniques, and the second generation protein refers to a treatment period through an increase in half-life or sustained release of the first generation protein. It means biopharmaceuticals that have been improved through modification of the formulation technology or molecular structure for the purpose of prolonging the effect. The present invention provides a powerful means for easily accomplishing this purpose by simply mixing and adsorbing first or second generation protein drugs with drug carriers, unlike existing technologies requiring modification of the protein itself or introduction of specific molecular structures. Providing. Therefore, applying the technology of the present invention to protein drugs can significantly shorten the next-generation drug development period and can effectively contribute to enhancing the value of use of hydrophobic synthetic drugs. Ultimately, the technology of the present invention can be very usefully applied to the development of new drugs such as product-release sustained-release proteins and synthetic medicines. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101279022-B1 |
| priorityDate | 2008-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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