| abstract |
The present invention relates to polynucleotides comprising chromatin opening elements (UCOEs) that are not derived from positional regulatory regions (LCRs). The invention also relates to a vector comprising said polynucleotide sequence, a host cell comprising said vector, the use of said polynucleotide, vector or host cell in a method of treatment and analysis, and a method of identifying UCOEs. The UCOE opens chromatin or keeps chromatin open and promotes replicative expression of genes operably linked in cells of at least two different tissue types. |