http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20090104925-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57492 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-577 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate | 2002-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20090104925-A |
| titleOfInvention | Methods for Recognition of Polypeptide Antigens Associated with Diseases Including Abnormal Cell Proliferation and Compositions Useful for the Treatment of Diseases |
| abstract | Methods and compositions are provided for the development of effective cancer therapies using mitotic inhibitors with limited general toxicity to normal non-cancer cells and tissues. The methods and compositions utilize cytotoxic compounds consisting of cell-binding agents (eg antibodies) conjugated to anti-mitotic compounds (eg maytansinoids). The invention provides that the therapeutic effect is not due to indirect cell killing by ADCC and / or CDC by substantially inducing antibody-dependent cell-mediated cytotoxicity (ADCC) and / or complement dependent cytotoxicity (CDC). Further provided are antibodies that can ensure that they are primarily mediated by the anti-mitotic component of the cytotoxic compound. Antibodies of the invention can distinguish polypeptide antigens that are more highly expressed in proliferative cancer cells as compared to proliferative non-cancer cells. |
| priorityDate | 2001-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1068.