| abstract |
2-aryl-4-quinolone is converted to phosphate by reaction with tetrabenzyl pyrophosphate to form dibenzyl phosphate, which is then hydrogenated to replace the dibenzyl group with H, and Amberlite IR-120 (Na + form) To form a disodium salt. As a result of prior selection, these phosphates showed a significant anticancer effect. New intermediates, N, N -dialkylaminoalkyl derivatives of 2-selenophen-4-quinolone and 2-phenyl-4-quinolone have also been synthesized. These new intermediates showed significant anticancer activity. |