| abstract |
The present invention is stable metastine having excellent biological activity (cancer metastasis inhibiting activity, cancer growth inhibitory activity, gonadal stimulating hormone secretion stimulating activity, sex hormone secretion stimulating activity, gonadal stimulating hormone secretion inhibitory activity, sex hormone secretion inhibiting activity, etc.) It provides a derivative. By replacing the constituent amino acids of metastin with specific amino acids, the metastin derivative of the present invention further improves blood stability, solubility, etc., reduces the tendency to gel, improves pharmacokinetics, and also has excellent cancer metastasis inhibiting activity or cancer growth. Inhibitory activity was achieved. The metastin derivatives of the present invention also have gonadotropin secretion inhibitory activity, sex hormone secretion inhibitory activity and the like. |