abstract |
Various diseases and disorders related to the activity of cyclooxygenase and metabolic pathways associated with prostaglandin synthesis, such as type 2 diabetes and its sequelae, ischemic vascular disease, pain associated with inflammation, inflammatory skin symptoms, spinal cord injury, peripheral neuropathy , Multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis, and various forms of cancer can be treated or prevented by the use of agents that selectively increase the production of 15-deoxy-prostaglandin J2. Such compounds are 7-hydroxy-steroids or condensed indole. |