| abstract |
The present invention relates to synthetic peptide amide ligands of kappa opioid receptors, in particular agents of kappa opioid receptors that exhibit low P 450 CYP inhibition and low brain permeability. Synthetic peptide amides of the invention are in accordance with the following structural formula:n n n n n n n n Pharmaceutical compositions containing such compounds are useful for the prevention and treatment of pain and inflammation associated with various diseases or conditions. Such treatable pain includes visceral pain, neuropathic pain and hyperalgesia. Other diseases and conditions such as inflammation, ocular- and heteroinflammatory inflammation, pruritus, edema, hyponatremia, hypokalemia, intestinal obstruction, cough and glaucoma associated with conditions such as IBD and IBS can be treated or prevented using the pharmaceutical compositions of the present invention. Can be. |