abstract |
The present invention is directed to novel crystalline forms of poorly water-soluble salts of zoledronic acid, methods for preparing these crystalline forms, compositions containing these crystalline forms, and the use of these crystalline forms in diagnostic methods or therapeutic treatments of warm-blooded animals, in particular humans. It is about. The present invention provides a crystalline form of the free acid monohydrate of zoledronic acid, a method for producing a crystalline form of the free acid monohydrate of zoledronic acid, a composition containing the crystalline form of the free acid monohydrate of zoledronic acid, and a warm-blooded animal, In particular it relates to the use of crystalline forms of the free acid monohydrate of zoledronic acid in human diagnostic methods or therapeutic therapies. |