http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20090081830-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c419906858e635b9c06e115d9e2d37cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6827 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 |
| filingDate | 2008-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2e43f3920a0a2a23c39b66f92aeae80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8b3210cc84569c44d2ae0086ee17280 |
| publicationDate | 2009-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20090081830-A |
| titleOfInvention | SNP Gene Set for Diagnosing Aspirin-Sensitive Asthma |
| abstract | The present invention is to analyze the relationship between the rate of decrease of Forced Expiratory Volume in one second and single nucleotide polymorphism (SNP) after administration of aspirin, which is the standard for diagnosing aspirin-sensitive asthma. Provided is a set of SNP genes that can be diagnosed. In the present invention, genotyping was performed by selecting 1,536 SNPs from the NCBI SNP DB for the development of a SNP gene set for diagnosing aspirin-sensitive asthma. As a result, a total of 1,420 SNPs were successfully genotyped, and 527 SNPs with a minor allele frequency (MAF) of less than 0.1 and a P-value of multiple regression analysis for FEV1 reduction after aspirin administration were found. Primary SNP gene candidates were selected. A second analysis was performed with staged variable selection to develop a set of 24 SNP genes with high estimates of the FEV1 reduction rate after administration of aspirin of the present invention (P value <0.0001). The SNP gene set of the present invention suggests that aspirin-sensitive asthma can be diagnosed without administration of aspirin, which can be usefully used in new drug development, disease diagnosis, and treatment. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107142307-A |
| priorityDate | 2008-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.