| abstract |
The present invention provides novel compounds of Formula I wherein W 1 , W 2 , W 3 , W 4 , W 5 , B, X 1 , X 2 , X 3 , X 4 , X 5 , E and L As defined in the invention; Compounds of the invention are gamma amino butyric acid receptor-subtype B (“GABA B ”) and are positive allosteric modulators (enhancers), which are anxiety, depression, epilepsy, schizophrenia, cognitive impairment, myotonic and skeletal muscle stiffness, Spinal Cord Injury, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Cerebral Palsy, Neuropathic Pain, and Cocaine and Nicotine-Related Needs, Panic Disorder, Traumatic Stress Incontinence, Gastroesophageal Reflux Disease, Transient Esophageal Sphincter Relaxation, Functional Gastrointestinal Methods of treating and preventing diseases or disorders are provided, including treatment of disorders and irritable bowel syndrome. |