http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20090079251-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3cde10605b30794fd676f517ea84dddf |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y30-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N1-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N1-30 |
| filingDate | 2007-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a08523e0c50c5370286b5d1714fd668 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3e991b5a6e8f12431bbddd7412f0a42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08601d1debb3e00d3ac14e68501f8901 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2efe8a49e7ee01b6b1937cd3286402a9 |
| publicationDate | 2009-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20090079251-A |
| titleOfInvention | Tissue preservation and fixation method |
| abstract | The present invention is capable of immobilizing and stabilizing cellular phosphoproteins, preserving cell morphology, and freezing of the cryostats for molecular analysis, for example, upon contact with a sample comprising a phosphoprotein at room temperature. (cryostat) relates to a composition that may make it possible to produce frozen sections. The composition comprises (1) an anchoring agent effective for immobilizing the phosphorus protein and having a water content sufficient for the stabilizer and / or permeability enhancer to be soluble; (2) stabilizers comprising (a) kinase inhibitors, (b) phosphatase inhibitors, and optionally (c) protease (eg, protease) inhibitors; (3) a permeation enhancer (eg PEG). A method of preserving phosphoproteins using the composition is described. Endogenous surrogate markers for monitoring proteolysis, including loss of modification (eg, phosphorylation) after translation, eg, after isolation of cells or tissues from the subject; And exogenous molecular sentinels (e.g., phosphoproteins attached to magnetic nanoparticles) that allow for evaluating the processing history of a cell or tissue population sample. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011071727-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011071727-A3 |
| priorityDate | 2006-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1321.