| abstract |
The inventors of the present invention found that 1) bone marrow-derived cells are mobilized in large amounts in the transplanted skin, and 2) the recruited bone marrow-derived cells are derived from dermal fibroblasts, adipocytes, muscle cells, vascular endothelial cells, and epidermal keratinocytes in the transplanted skin fragments. Bone marrow-derived mesenchymal stem cells are included in the differentiated and recruited bone marrow-derived cells, and 3) the recruitment of bone marrow-derived mesenchymal stem cells from peripheral blood to transplanted skin fragments is performed in necrotic tissue of transplanted skin. HMGB1, HMGB2, and HMGB3 released, 4) Purified HMGB1, HMGB2, and HMGB3 promote the migration of mesenchymal stem cells isolated and cultured from bone marrow; It can easily purify the active material from a number of organ extracts, including the skin, brain, heart, 6) Easily add the active material to the bone marrow mesenchymal stem cells in culture cells What you can do, 7) it revealed that the heparin-column purified fraction of skin extract mobilize bone marrow-derived cells in large quantities during brain injury for the first time in the world. |