abstract |
The present invention relates to novel piperidine or piperazine substituted tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion / MTP inhibitory activity and accompanying lipid lowering activity. The present invention also provides methods of preparing such compounds, pharmaceutical compositions comprising the compounds, and for treating atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type 2 diabetes. It relates to the use of the compound as a medicament. |