| abstract |
The present invention provides N, N'-dihydroxyamidine (I), N, N'-dihydride as a substituent of the amidine functional group of the pharmaceutical substance in the drug in order to enhance the bioavailability of the pharmaceutical substance. Roxiamidine ether (II), N, N'-dihydroxyamidine diether (III), N, N'-dihydroxyamidine ester (IV), N, N'-dihydroxyamidine di To the use of ester (V) or 4-hydroxy-1,2,4-oxadiazoline (VI), wherein R is a hydrogen, alkyl radical and / or aryl radical. |