| abstract |
The present invention relates to a method for producing a transgenic cloned dog, and more specifically, to remove a nucleus from an oocyte of a dog, to prepare a denuclear egg and to transplant a cell transformed with a gene of interest to the denuclear egg to prepare a nuclear transfer egg. The present invention relates to a method for producing a cloned dog into which a target gene has been introduced, which is characterized by transplanting it into a surrogate mother. The present invention has confirmed the possibility of mass production of disease model animals by the successful introduction of foreign genes, which is useful in the field of veterinary medicine, anthropology and medical research, such as breeding of superior breeds, xenotransplantation, disease model animals. |