| abstract |
Urea compounds that inhibit soluble epoxide hydrolase (sEH), their stereoisomers or pharmaceutically acceptable salts, and compositions, methods of making these compounds and compositions, and methods of treating patients with these compounds and compositions It starts. The compounds, compositions and methods are useful for treating a variety of sEH mediated diseases including hypertension, cardiovascular, inflammatory, pulmonary and diabetes-related diseases. Formula I, wherein X is C═O or SO 2 ; Y is selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; Z is independently selected from the group consisting of halogen and haloalkyl; n is an integer equal to 1, 2, or 3; And p is an integer equal to 1, 2, or 3.n n n n n n n n I |