| abstract |
The present invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions, and the development and / or progression of a disease or disorder in response to nitroxyl therapy, including heart failure and ischemia / reperfusion injury Is useful for treating and / or preventing. The novel N-hydroxysulfonamide derivatives release NHO at controlled rates under physiological conditions, and the rate of HNO release is controlled by changing the nature and position of the functional groups of the N-hydroxysulfonamide derivatives. |