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publicationDate 2009-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20090056095-A
titleOfInvention A composition for preventing vascular restenosis comprising a cell adhesion factor expression gene inhibitor of vascular endothelial cells and a stent coated therewith
abstract The present invention is to use a substance that inhibits the cell adhesion factor expression gene of vascular endothelial cells in the drug-release stent used for vascular stenosis, more specifically, Shizukaol B, cyclosijukaol A defined by the following Chemical Formulas 1 to 3 And a composition for preventing vascular restenosis and a stent coated with the composition, including an inhibitor of vascular endothelial cell expression gene expression, comprising a compound selected from the group consisting of Shizukaol F.n n n The organ or vascular restenosis prevention composition and stent coated with the same according to the present invention reduce the re-adhesion and infiltration of blood cells such as monocytes, neutrophils and lymphocytes into the blood vessel wall and restenosis caused by various causes after the stent procedure. It is effective to prevent).
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