| abstract |
The present invention starts at the amino terminus of a protein, followed by (i) cytomegalovirus human MHC-restricted peptide, (ii) first peptide linker, (iii) human β-2 microglobulin, (iv) second peptide linker, (v) ) The HLA-A2 chain of the human MHC class I molecule, (vi) the third peptide linker, (vii) the variable region from the heavy chain of the scFv fragment of the antibody, and (viii) the variable region from the light chain of the scFv fragment. Provided is a fusion protein comprising a contiguous amino acid corresponding to a contiguous amino acid present, wherein the contiguous amino acids corresponding to (vii) and (viii) are either directly linked by peptide bonds or contiguous corresponding to a fourth peptide linker. And the scFv fragments are derived from an antibody that specifically binds to mesothelin. The present invention provides a nucleic acid construct encoding the fusion protein, a method for preparing the fusion protein, a composition and a use thereof.n n n n Fusion Proteins, Tumors, Peptides, Mesothelins |