| abstract |
Substituted bicyclic and tricyclic modified Himbasin derivatives or pharmaceutically acceptable salts or solvates of the compounds, as well as pharmaceutical compositions comprising them, and thrombosis, atherosclerosis by administering the compounds It describes how to treat diseases associated with restenosis, hypertension, angina, arrhythmia, heart failure, and cancer:n n n Formula In n n n n n n n In the above formula,n n n (DU) represents any double bond,n n n E n , F n , G n , Z n , J n , X, R 3 , R 9 , R 10 , R 11 , R 32 , R 33 , B and Het are as defined herein.n n n Also claimed are combination therapies with other agents. |