abstract |
The present invention provides a means for high secretion production of proteins, particularly proteins having complex structures, such as antibodies, in host cells such as yeast.n n n According to the present invention, a transformed yeast having an active HAC1 gene and an RRBP1 gene, and a method for producing a high-secretion of foreign protein by using the transformed host cell and suppressing O-type sugar chains specific to host cells such as yeast This is provided. |