abstract |
The present invention relates to a human antibody or antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a K D of about 500 pM or less and blocks IL-6 activity with an IC 50 of 200 pM or less. The antibody or antibody fragment binds hIL-6R with at least two times higher affinity compared to its binding to monkey IL-6R.n n n Human interleukin-6 receptor (hIL-6R), anti-hIL-6R antibody, high affinity antibody, surface plasmon resonance, IL-6-mediated disease |