| abstract |
A novel vinylazacycloalkane compound of formula (I) is disclosed. Compounds of the invention are ligands of various nAChRs. The compounds of the present invention and pharmaceutically acceptable salts thereof are particularly for the prevention or treatment of diseases associated with the malfunction of nAChRs in the central nervous system or gastrointestinal tract. Examples of the types of diseases that can be treated include Alzheimer's disease, cognitive disorders, motor disorders such as Parkinson's disease, drug addiction, behavioral disorders, and inflammatory diseases in the gastrointestinal tract. The compounds of the present invention may also act as analgesics in the treatment of acute, chronic, or recurrent pain. |