abstract |
Provided is a controlled release composition comprising a high amount of bioactive material, inhibiting excessive initial release, and achieving stable release rates over a long period of time. The controlled release composition comprises (1) a bioactive substance or salt thereof in an amount of about 14% (w / w) to about 24% (w / w) based on the total composition weight, (2) 3-hydroxy-2-naph Hydroxynaphthoic acid selected from the group consisting of tomic acid and 1-hydroxy-2-naphthoic acid or salts thereof, and (3) a weight average molecular weight of 15000 to 50000 having a content of a polymer having a molecular weight of 5000 or less and about 5% by weight or less. Lactic acid polymers or salts thereof, and the molar ratio of hydroxynaphthoic acid or salts thereof to bioactive substances or salts thereof is 3: 4 to 4: 3. |