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publicationDate 2009-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20090018707-A
titleOfInvention Pyrrolidine derivatives useful as bace inhibitors
abstract Novel 3-mono, 3,4-disubstituted and 3,4,4-trisubstituted pyrrolidine compounds; For use in diagnostic and therapeutic treatment of warm-blooded animals, in particular dependent on the activity of beta-secretase, and / or the production of beta-amyloid and subsequent aggregation into oligomers and fibrils (= disorders) These compounds for treatment; The use of compounds of this class for the manufacture of pharmaceutical preparations for the treatment of diseases dependent on the activity of beta-secretase and / or the production of beta-amyloid and subsequent aggregation into oligomers and fibrils; The use of compounds of this class in the treatment of diseases dependent on the activity of beta-secretase and / or the production of beta-amyloid and subsequent aggregation into oligomers and fibrils; Pharmaceutical formulations comprising the substituted pyrrolidine compounds and / or methods of treatment comprising administration of the substituted pyrrolidine compounds are described. Substituted pyrrolidine compounds are especially compounds of formula (I) wherein the substituents are as described in the specification.n n n <Formula I>
priorityDate 2006-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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