| abstract |
Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing such compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivative is a ligand of the δ-opioid receptor and, in particular, of pain, anxiety, gastrointestinal disorders, and other δ-opioid receptor-mediated diseases, disorders, and / or conditions It may be useful for treatment and / or prevention. |