abstract |
The present invention is useful for the treatment of cancer, B-cell malignancies, malaria, fungal infections, central nervous system diseases, neurodegenerative diseases, angiogenesis dependent diseases, autoimmune diseases and / or prophylactic pretreatment of cancers. ) Or a 17-oxymacbecin analogue according to (IB) or a pharmaceutically acceptable salt thereof, wherein R 1 is H, OH or OCH 3 ; R 2 is H or CH 3 ; R 3 is H or CONH 2 ; R 4 and R 5 each represent H or both together represent one bond (ie, C 4 to C 5 are double bonds); R 6 is H or OH; And R 7 is H or CH 3 . The invention also provides methods for the preparation of said compounds and their medicinal uses, in particular for the treatment and / or prophylaxis of cancer or B-cell malignancies. |