http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20080112306-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5053f82a7cd17c60822674b657cfb89e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-08 |
| filingDate | 2007-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_704687061e0711073c0cfbce1153a0aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82c0b149e39d02a5f406c99a8d3b5455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a432b9f49306df87880c68911772d12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e13f5514fa42ebfb804c3bcc5c58a4d |
| publicationDate | 2008-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20080112306-A |
| titleOfInvention | 4- [1- (4-cyanophenyl) -1- (1,2,4-triazol-1-yl) methyl] benzonitrile and 4- [1- (1H-1,2,4-triazole Synthesis of -1-yl) methylene benzonitrile intermediate |
| abstract | The present invention provides a process for the preparation of 4- [1- (4-cyanophenyl) -1- (1,2,4-triazol-1-yl) methyl] benzonitrile (retrozole) substantially free of isomeric impurities. It is about. The preparation method comprises the reaction of 4- [1- (1H-1,2,4-triazol-1-yl) methylene benzonitrile with 4-fluorobenzonitrile in the presence of an organic solvent and a silicone amine. The present invention also relates to (a) reacting 4-halomethyl benzonitrile with 1,2,4-triazole in the presence of cesium carbonate and an organic solvent to form 4- [1- (1,2,4-triazole of formula II. -1-yl) methyl] obtaining a reaction mixture comprising benzonitrile; And (b) precipitating 4- [1- (1,2,4-triazol-1-yl) methyl] benzonitrile (II) from the reaction mixture using a suitable organic solvent. A method for producing [1- (1H-1,2,4-triazol-1-yl) methylene benzonitrile. |
| priorityDate | 2006-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 139.