| abstract |
The present invention relates to compounds of formula (I) which inhibit protein tyrosine kinases, in particular c-fms kinases, and solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof:n n n n n n n n Wherein Z, X, J, R 2 and W are as described herein.n n n Treating diseases with autoimmune diseases and inflammatory components with a compound of formula (I); To treat metastasis of ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; Treating pain including skeletal pain or visceral, inflammatory, and neurological pain due to tumor metastasis or osteoarthritis; Osteoporosis, Paget's disease, and other forms of rheumatoid arthritis and inflammatory arthritis, osteoarthritis, artificial joint disorders, osteolytic sarcomas, myeloma and other diseases that mediate pathological conditions, including bone metastases to bone, Is provided. |