| abstract |
Compounds of formula (I), wherein groups are defined in the specification, are useful for the manufacture of drugs for the treatment of cardiovascular disorders, in particular cardiac dysfunction and hypertension. This compound is an inhibitor of the enzymatic activity of Na + , K + -ATPase. These include the treatment of diseases caused by the hypertensive effects of endogenous uvine, such as autosomal dominant polycystic kidney disease (ADPKD), autologous hypertension and renal failure progression in patients with proteinuria and renal failure progression in patients with fatherhood polymorphism. Useful in the manufacture of drugs for |