| abstract |
The present invention is directed to modified cDNA sequences encoding Factor X polypeptides, in particular human Factor X and derivatives thereof, which may bypass the need for Factor VIIIa / FIXa or Factor VIIa / TF for activation. The invention also relates to recombinant expression vectors containing such modified cDNA sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives having the biological activity of unmodified wild-type proteins, but with altered activation properties, and such It relates to a method for producing a recombinant protein and its derivatives. The invention also relates to a transfer vector for use in human gene therapy comprising such modified DNA sequences. |