http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20080099745-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2f40b30ca35b7bcedbf3fdd6dfa76640 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 |
| filingDate | 2007-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e868a73b20656d8b41b9b46f4073a206 |
| publicationDate | 2008-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20080099745-A |
| titleOfInvention | Cilostazol composition for the treatment of osteoarthritis |
| abstract | The present invention relates to a cilostazol composition for protecting rat chondrocytes from NO-induced apoptosis through PKCK2 and preventing or treating cartilage tissue destruction in osteoarthritis, wherein the composition according to the present invention is a rat from NO-induced cell death. Protects articular chondrocytes, prevents down-regulation of NO-induced HO- 1 as well as up-regulation of phosphorylated p38 and p53, prevents the release of mitochondrial apoptosis factors and activation of caspases, phosphorylates to cytosol and nucleus Accumulate Bid and prevent NO-induced downregulation of PKCK2 expression level and prevention of PKCK2 activity, as well as preventing NO-induced apoptosis through PKCK2, preventing cartilage tissue destruction and chondrocyte apoptosis There is. |
| priorityDate | 2007-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 340.