| abstract |
The present invention identifies novel small-molecule Trp-p8 modulators, including small-molecule Trp-p8 modulators comprising Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists. And to reduce the viability of Trp-p8 expressing cells and / or to inhibit the growth of cells, to activate Trp-p8-mediated cation influx, apoptosis and / or Provided are methods for stimulating necrosis, and for treating diseases associated with Trp-p8 expression, including cancer, such as lung cancer, breast cancer, colorectal cancer, and / or other diseases, such as benign prostatic hyperplasia It is related to the relevant method. |