| abstract |
The present invention provides compounds of formula (I), N-oxides, pharmaceutically acceptable salts, stereochemically isomers or solvates thereof, wherein X represents N or CH; Y is a direct bond, CH 2 -C ( = O) (wherein CH 2 is bonded to N of the piperidine ring), C (= 0) or S (= 0) p ; p represents an integer of 1 or 2; R 1 represents CH (R 4) - aryl or CH (R 4) - represents a heteroaryl group; R 2 is aryl 2, or represents a heteroaryl group; R 3 is C 1 hydrogen, C 1-6 alkyl, poly-to-6 alkyl, C 1 - relates to 7 denotes a cycloalkyl, amino, or mono or di (C 1-4 alkyl) amino) - 6 alkyloxy, aryl 1, aryl 1 -NH-, heteroaryl, heteroaryl -NH-, C 3. The present invention provides the use of a compound of formula (I) for the manufacture of a medicament for the prevention or treatment of a disease mediated through the activation of a CXCR3 receptor; A method for preparing a compound of formula (I) and a pharmaceutical composition comprising the same. |