| abstract |
The present invention relates to (a) N- {5- [4- (4-methyl-piperazino-methyl) -benzoylamido] -2-methylphenyl} -4- (3-pyridyl) -2-pyrimidine- A combination comprising an amine and (b) an anti-neoplastic agent, in particular an anti-neoplastic agent as defined herein and a chemotherapeutic agent selected from agents effective for treating acute or chronic graft rejection, is a warm-blooded animal suffering from proliferative disease or acute or chronic graft rejection A method of treating said animal, particularly comprising administering to a human; And (a) and (b) as defined above, and optionally one or more pharmaceutically acceptable carriers, simultaneously, separately or sequentially for the purpose of delaying or treating the proliferative disease, in particular solid tumor disease It relates to a formulation for use. |