| abstract |
The present invention relates to a moldable biocompatible material comprising a particulate solid porous material and a biodegradable paste material. The paste material and particulate solid porous material form a substrate that can be used to replace or augment bone. In various embodiments, the substrate has high structural integrity (which does not collapse into an amorphous nonporous mass immediately after or shortly after implantation), maintains its porosity after implantation, shows biphasic degradation after implantation and / or is wet It has good resistance to washing when applied to open graft sites. Active agents, such as bone growth factors, can be incorporated into the moldable biocompatible materials of the present invention. Also provided are kits, implants, methods of manufacture, as well as medical uses. |