http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20080078615-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fb65ab1b41c2067a40270436dc55a429 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2521-319 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2521-301 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2563-107 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6834 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6876 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2008-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_627e50c01e5dfc8db1c8511ef8995d3e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_854b11c535caba3bcab12f278f15ee1f |
| publicationDate | 2008-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20080078615-A |
| titleOfInvention | Methods, compositions and kits for increasing the hybridization efficiency or specificity of a PNA probe and target nucleic acid immobilized on a support |
| abstract | In the present invention, a target nucleic acid is fragmented by using a nuclease in a hybridization reaction of a PNA (Peptide Nucleic Acid) probe and a target nucleic acid immobilized on a support, or the size of the target nucleic acid is reduced or mismatched with the PNA probe. A method, composition and kit for increasing the hybridization efficiency or specificity between a target nucleic acid and a PNA probe immobilized on a support, comprising selectively cleaving a mismatched target nucleic acid. According to the present invention, it is possible to easily distinguish single nucleotide polymorphism (SNP) by increasing the sensitivity and specificity of the hybridization reaction in the PNA chip, and to analyze long target nucleic acids without undergoing complex amplification and pretreatment. In addition, multiple SNPs or mutations in long target nucleic acids can be detected by one target nucleic acid amplification. |
| priorityDate | 2007-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.