abstract |
The present invention is directed to anti-α2 integrin antibodies and uses thereof. The present disclosure discloses that humanized antibodies bind the I region of α2 integrin and inhibit the interaction of α2β1 integrin with collagen. Also disclosed are therapeutic uses of anti-α2 integrin antibodies in the treatment of α2β1 related diseases, including anti-α2 integrin antibodies that bind α2 integrin without activating platelets.n n n n Anti-alpha2 integrin antibody, region I, collagen, platelets, multiple sclerosis |