| abstract |
The present invention provides the use of the compound and the in vitro use in the manufacture of a medicament for treating an immunostimulatory composition and a disease. In particular, the compositions of the present invention comprise immunostimulatory oligoribonucleotides incorporating sequence-dependent immunostimulatory sequence motifs. Certain variants, nucleotide analogues, adducts, and combinations thereof, including phosphate bonds, are provided. Compositions of the present invention, which may or may not include an antigen, may be used alone or in combination with other therapeutic agents to stimulate or augment an immune response. Also provided are compositions and methods useful for treating a subject having an infection, cancer, allergic disease, asthma, airway remodeling or immunodeficiency. The immunostimulatory oligoribonucleotides of the invention are thought to stimulate Toll-like receptor 8 (TLR8). |