| abstract |
The present invention provides methods and compositions for the treatment of ion imbalance with core-shell complexes, and compositions comprising such core-shell complexes. In particular, the present invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and the pharmaceutical compositions in each case. Also disclosed are methods of using polymeric and pharmaceutical compositions for therapeutic and / or prophylactic benefits. The compositions and methods of the present invention provide an improved approach to treat hyperkalemia and other symptoms associated with potassium ion homeostasis, and an improved approach to treat other symptoms associated with hypertension and sodium ion homeostasis. |