| abstract |
The present invention relates to proteinaceous compositions exhibiting reduced antigenic biological activity as well as methods for lowering antigenicity of such compounds while maintaining the biological activity of the proteinaceous compounds. These methods and compositions are of considerable benefit to a subject in need thereof. Also included are modified toxin compounds that have cleaved and / or degraded antigenicity. Such designer toxins have in particular therapeutic, diagnostic and prophylactic advantages as immunotoxins. Methods of treating cancer using these immunotoxins are provided. |