| abstract |
The present disclosure provides isolated monoclonal antibodies, in particular human monoclonal antibodies, that specifically bind to CD70 with high affinity. Also provided are nucleic acids encoding antibodies of the present disclosure, expression vectors for expressing antibodies of the present disclosure, and host cell light expression methods. Also provided are immunoconjugates, bispacific molecules, and pharmaceutical compositions comprising the antibodies of the disclosure. The present disclosure also provides methods of treating cancer, autoimmune diseases, inflammatory and viral infections. |