| abstract |
The present invention relates to formula (III) wherein R 1 , R 2 , R 3 , n, X and R 5 are as defined for formula (II) and the group R 4 ′ is a group R 4 or a precursor thereof Aromatization of the compound), and if necessary or desired, the following steps: (i) removing any hydroxy protecting group R, (ii) precursor group R 4 ' to group R Converting to 4 or, if the group R 4 ' is a group R 4 , converting the group R 4' to another such group to form an intermediate of formula (II), wherein X is as defined in the specification , R 1 is haloalkyl, alkyl, alkenyl, cycloalkyl carboxyalkyl, alkoxycarbonylalkyl, aryl or arylalkyl, and R 2 , R 3 , R 4 and R 5 are organic groups as defined in the specification) It provides a method for preparing the compound. The obtained compound is an intermediate useful for producing fulvestrant, for example, and novel intermediates are also claimed. |