| abstract |
The present invention relates generally to the fields of immunology, gene therapy and vaccine technology. More specifically, the present invention relates to a novel system capable of rapidly generating high titer adenovirus vectors that do not contain replication-competent adenovirus (RCA). In addition, a method for generating such an RCA-free adenovirus vector, an immunogenic or vaccine composition containing the RCA-free adenovirus vector, a method for expressing the heterologous nucleic acid in the adenovirus vector, and using the adenovirus vector Methods of inducing an immunogenic response are provided. |