http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20080040674-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2462 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1136 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 |
| filingDate | 2006-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f2cf7e13fd117d078af5ce1aa08c95a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_493497525f33e9a00ee2d72b05418a9d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80749ecab97175c7aa2bb64471cc1599 |
| publicationDate | 2008-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20080040674-A |
| titleOfInvention | Methods and apparatus for in vitro protein folding |
| abstract | The method of recovering the refolded protein requires static mixing of the refolding diluent with a concentrated solution of the denatured protein to obtain the refolded protein. The method is particularly suitable for recombinant proteins produced by microorganisms at large doses. The denatured protein solution can be obtained by separating the protein from the microbial host and exposing it to a denaturant. This solution is mixed with an appropriate refolding diluent under static mixing conditions that are compatible with the proper folding of the protein so that the refolded protein can be obtained as quickly as possible with high yield. The apparatus implementing the refolded protein recovery method includes a static mixer, a conduit located upstream of the static mixer, an inlet from the upstream of the static mixer to the conduit, and optionally, a static mixer. Downstream of it holds a dynamic, preferably non-turbulent mixing vessel. The present invention is particularly useful for large scale production of proteins, preferably recombinant proteins. |
| priorityDate | 2005-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.