| abstract |
Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection except for mycobacterial infection, the compound comprising a compound of formula (la) or formula (lb), a salt thereof, a pharmaceutically acceptable acid or base addition salt thereof, Quaternary amines, stereochemically isomers thereof, tautomers or N-oxides thereof: wherein R 1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio , Alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di (Ar) alkyl; p is 1, 2, 3 or 4; R 2 is hydrogen, hydroxy, thio, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di (alkyl) amino or a radical of formula (II); R 3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; R 4 is hydrogen, alkyl or benzyl; R 5 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di (Ar) alkyl; Alternatively, two adjacent R 5 radicals together may form naphthyl together with the phenyl ring to which they are attached; r is 1, 2, 3, 4 or 5; R 6 is hydrogen, alkyl, Ar or Het; R 7 is hydrogen or alkyl; R 8 is oxo; R 7 and R 8 together form the radical —CH═CH—N =; Z is CH 2 or C (═O). |