| abstract |
The present application relates to sustained injectable (LAI) formulations for eradicating ectoparasites and endoparasites in mammals. In particular, the present invention provides LAI formulations comprising subcutaneous volatile solvents, biologically acceptable polymers, bioactive agents, optionally one or more anti-ectoparasitic or anti-endoparasitic acceptable additives or excipients.n n n Surprisingly, the liquid long-acting injectable formulations of the present invention have long-term stability in liquid form to accommodate smaller needle diameters, and provide convenient dosage forms for achieving a lasting effect on the control of pests in mammals, thereby allowing conventional injections. Solve problems with possible formulations. The unique formulation of the present invention also kills ectoparasites and endoparasites that have become resistant to macrolide antibiotics. |