| abstract |
The present invention relates to amino alcohol derivatives or phosphonic acid derivatives having excellent immunosuppressive action, pharmacologically acceptable salts thereof or pharmacologically acceptable esters thereof and pharmaceutical compositions containing them:n n n [Formula I]n n n n n n n n [Wherein, R 1 and R 2 each represent a hydrogen atom and a protecting group of an amino group; R 3 is a hydrogen atom, a protecting group of a hydroxyl group; R 4 is a lower alkyl group; n is an integer from 1 to 6; X is a nitrogen atom substituted with an oxygen atom or an unsubstituted or lower alkyl group; Y is an ethylene group; Z is a C 1 -C 10 alkylene group; R 5 is an aryl group, a substituted aryl group; R 6 and R 7 each represent a hydrogen atom; Provided that when R 5 is a hydrogen atom, Z represents a group other than a single bond and a straight C 1 -C 10 alkylene group.] |