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publicationDate 2008-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20080035666-A
titleOfInvention Quinoline derivatives as antimicrobials
abstract Use of a compound of formula (I), a pharmaceutically acceptable acid or base addition salt, quaternary amine, stereochemical isomer, tautomer or N-oxide form, for the manufacture of a medicament for the treatment of bacterial infections except mycobacterial infection Is initiated:n n n n n n n n Wheren n n R 1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di (Ar) alkyl;n n n p is an integer from 1 to 3;n n n s is an integer from 0 to 4;n n n R 2 is hydrogen; Halo; Alkyl; Hydroxy; Mercapto; Optionally substituted alkyloxy; Alkyloxyalkyloxy; Alkylthio; Mono or di (alkyl) amino, wherein alkyl may be optionally substituted; Ar; Het or expression Is a radical of;n n n R 3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl;n n n q is an integer from 0 to 4;n n n R 4 and R 5 are each independently hydrogen, alkyl or benzyl;n n n R 4 and R 5 may be bonded together, including the N to which they are attached;n n n R 6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di (Ar) alkyl;n n n Two adjacent R 6 radicals together may form naphthyl with the phenyl ring to which they are attached;n n n r is an integer from 1 to 5;n n n R 7 is hydrogen, alkyl, Ar or Het;n n n R 8 is hydrogen, alkyl, hydroxyl, aminocarbonyl, mono or di (alkyl) aminocarbonyl, Ar, Het, alkyl substituted by 1 or 2 Het, or alkyl substituted by 1 or 2 Ar , Het-C (= 0)-or Ar-C (= 0)-;n n n Provided that R 3 is located at position 3 of the quinoline moiety;n n n R 7 is located at position 4 of the quinoline moiety;n n n R 2 is located at position 2 of the quinoline moiety and is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di (alkyl) amino or a formula When it is a radical of;n n n s is 1 to 4.
priorityDate 2005-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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